Most reversed-phase LC/MS separations of peptides or proteins utilize formic acid to avoid issues with salts and ion suppression. However, TFA in UV provides the best peak shape. Are there any other additives to consider?
Is compromising sensitivity and peak shape the only option? Trust Your Science, ep 22
Most reversed-phase LC/MS separations of peptides or proteins utilize formic acid to avoid issues with salts and ion suppression. However, TFA in UV provides the best peak shape. Are there any other additives to consider?
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