Which cancers spread (metastasize) to the brain? Many cancers can spread to the brain. The five most common cancers that metastasize to the brain are lung, breast, skin, kidney, and GI.
Brain metastasis occurs in approximately 25 percent of all cancer patients.
Patients with small cell lung cancer have a 60 to 80% risk of developing brain metastasis within two years of initiation of treatment.
Approximately 40% of all patients diagnosed with melanoma will develop brain metastasis.
Brain metastases are about 10 times more common than primary tumors.
Approximately 70 percent of patients who die with metastatic cancer will have brain metastasis on autopsy.

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