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The role of Probiotics and Gut Health on Inflammation - Thomas DeLauer
Gut Bacteria/Microbes Differs from Person to Person
A healthy human gut is teeming with microbes, with bacterial cells outnumbering other cells in the body by 10-to-1.
The gut microbiota regulates metabolic function and energy balance, and an altered microbial ecology contributes to the development of several metabolic diseases including obesity.
The gut community in lean people is brimming with many species but that the community in obese people is less diverse.
Bacteria species possessing anti-inflammatory properties, is increased significantly in lean people, but bacteria species possessing pro-inflammatory properties increased in obese people.
Study
One study in the Nature Journal examined the gut bacteria in 77 pairs of twins, one of whom was obese and one of whom was not.
The study found that those who were obese had different gut bacteria than their non-obese twins.
In particular, obesity was associated with lower gut bacteria diversity, meaning there were fewer types of bacteria in the gut.
The results reveal that the human gut microbiome is shared among family members, but that each person's gut microbial community varies in the specific bacterial lineages present
Gut Bacteria Affects Inflammation
A review by the Journal of Nutrients from in vitro studies suggests that known and potential probiotics exhibit strain-specific anti-inflammatory effects.
For example, Bifidobacteria is a type of species of bacteria that help maintain a healthy gut barrier and prevent inflammatory chemicals from passing from the gut into the bloodstream.
Probiotics Reduce Lipopolysaccharides
In a study in the Journal of Alimentary Pharmacology & Therapeutics, 30 patients with cirrhosis (liver damage), Lactobacillus taken for 8 weeks lowered lipopolysaccharide (LPS) levels.
Resources
1)Turnbaugh PJ , et al. (n.d.). A core gut microbiome in obese and lean twins. - PubMed - NCBI. Retrieved from
2)Hjorth MF , et al. (n.d.). Pre-treatment microbial Prevotella-to-Bacteroides ratio, determines body fat loss success during a 6-month randomized controlled diet intervention. - PubMed - NCBI. Retrieved from
3)Scientists identify mechanisms driving gut bacterial imbalance and inflammation. (2018, 11). Retrieved from
4)Wallis, C. (2014, June 1). How Gut Bacteria Help Make Us Fat and Thin. Retrieved from
5)Comparison of the gut microbial community between obese and lean peoples using 16S gene sequencing in a Japanese population. (n.d.). Retrieved from
6)Saltiel AR and Olefsky JM. (n.d.). Inflammatory mechanisms linking obesity and metabolic disease. - PubMed - NCBI. Retrieved from
7)Cani PD , et al. (n.d.). Metabolic endotoxemia initiates obesity and insulin resistance. - PubMed - NCBI. Retrieved from
8)The microbes in your gut may be making you fat. (2013, December 9). Retrieved from
9)The gut microbiota and its relationship to diet and obesity: New insights. (1, May). Retrieved from
10)Gut microbiota: Definition, importance, and medical uses. (n.d.). Retrieved from
11)Bajaj JS , et al. (n.d.). Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis. - PubMed - NCBI. Retrieved from
12)Rodes L , et al. (n.d.). Effect of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharides and inflammatory cytokines: an in vitro study using a hum... - PubMed - NCBI. Retrieved from
13) Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases. (n.d.). Retrieved from
14) Gram Negative Bacterial Inflammation Ameliorated by the Plasma Protein Beta 2-Glycoprotein I. (n.d.). Retrieved from
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